Alexion – 2025

To learn more about TMAs and aHUS diagnosis please visit tmasource.ca

Don’t Miss the Signs Identify the TMA

See the threat and stay ahead of the TMA Storm

The symptoms of TMA are non-specific (i.e., neurological impairment, organ system failure, GI manifestations).  Recognizing them early helps ensure your patients stay ahead of the storm.

Identify the TMA 

Patients with TMA present with the following clinical triad of laboratory signs and symptoms: 

⚠️ If you suspect TMA, a Hematology Consultation is Urgent!

⚠️ If you suspect Renal Impairment, a Nephrology Consultation is Urgent!

Watch: Thrombotic Microangiopathy, Suspected Atypical Hemolytic Uremic Syndrome 

A Webinar facilitated by Dr. Katerina Pavenski from St. Michaels (Toronto). Also available on YouTube.

Watch: What is Thrombotic Microangiopathy and
why should I care?

A symposium facilitated by Drs. Eddy Lang, Federico Germini, and Eric Tseng. Also available on YouTube.

Download the TMA Order Set for guidance on initial lab investigations, diagnostics, and supportive management here.

About Alexion

Alexion, AstraZeneca Rare Disease is focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and delivery of life-changing medicines. A pioneering leader in rare disease for more than three decades, Alexion was the first to translate the complex biology of the complement system into transformative medicines, and today it continues to build a diversified pipeline across disease areas with significant unmet need, using an array of innovative modalities. As part of AstraZeneca, Alexion is continually expanding its global geographic footprint to serve more rare disease patients around the world. Alexion has been operating in Canada since 2009 and has been working tirelessly to bring innovative medicines to the millions of Canadians living with rare diseases. 

Alexion-AstraZeneca-Logo

References: 

  1. Azoulay E, et al. Chest. 2017;152(2):424 434.
  2. Laurence J, et al. Clin Adv Hematol Oncol. 2016;14 Suppl 11(11):2-15.
  3. Caprioli J, et al. Blood. 2006;108:1267-1279.

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